Xiang Lab @ THU

Sulfur Chemistry for Modified Nucleic Acids as Tools in Chemical Biology

Full Publication List

As corresponding author since PI

Shang, J. C.; He, L.; Wang, J. Y.; Tong, A. J.; Xiang, Y.*, In Situ Visualizing Nascent RNA by Exploring DNA-Templated Oxidative Amination of 4-Thiouridine. Bioconjugate Chemistry, 2022, 33, 164-171.
Gu C. M.; Xiao, L.; Shang, J. C.; Xu, X.; He, L.; Xiang, Y.*,Chemical Synthesis of Stimuli-Responsive Guide RNA for Conditional Control of CRISPR-Cas9 Gene Editing. Chemical Science, 2021, 12, 9934-9945.
Xu, X.; Xiao, L.; Gu, C. M.; Shang, J. C.; Xiang, Y.*, Wavelength-Selective Activation of Photocaged DNAzymes for Metal Ion Sensing in Live Cells. ACS Omega, 2021, 6, 13153–13160.
Wang, J. Y.; Shang, J. C.; Qin, Z. C.; Tong, A. J.; Xiang, Y.*, Selective and Sensitive Fluorescence "Turn-On" Detection of 4-Thiouridine in Nucleic Acids via Oxidative Amination. Chemical Communications 2019, 55, 13096-13099.
Xiao, L.; Gu, C. M.; Xiang, Y.*, Orthogonal Activation of RNA-Cleaving DNAzymes in Live Cells by Reactive Oxygen Species. Angewandte Chemie-International Edition 2019, 58, 14167-14172.
Feng, M. L.; Gu, C. M.; Sun, Y. P.; Zhang, S. Y.; Tong, A. J.; Xiang, Y.*, Enhancing Catalytic Activity of Uranyl-Dependent DNAzyme by Flexible Linker Insertion for More Sensitive Detection of Uranyl Ion. Analytical Chemistry 2019, 91, 6608-6615.
Feng, M. L.; Ruan, Z. Y.; Shang, J. C.; Xiao, L.; Tong, A. J.; Xiang, Y.*, Photocaged G-Quadruplex DNAzyme and Aptamer by Post-Synthetic Modification on Phosphodiester Backbone. Bioconjugate Chemistry 2017, 28, 549-555.
Xiao, L.; Zhou, Z. J.; Feng, M. L.; Tong, A. J.; Xiang, Y.*, Cationic Peptide Conjugation Enhances the Activity of Peroxidase-Mimicking DNAzymes. Bioconjugate Chemistry 2016, 27, 621-627.
Xiao, L.; Xiang, Y.*, Quantification of Total Phosphorothioate in Bacterial DNA by a Bromoimane-Based Fluorescence Method. Biotechnology Journal 2016, 11, 824-830.
Wang, X. Y.; Feng, M. L.; Xiao, L.; Tong, A. J.; Xiang, Y.*, Postsynthetic Modification of DNA Phosphodiester Backbone for Photocaged DNAzyme. ACS Chemical Biology 2016, 11, 444-451.
Gu, C. M.; Xiang, Y.*; Guo, H. L.; Shi, H. C.*, Label-Free Fluorescence Detection of Melamine with a Truncated Aptamer. Analyst 2016, 141, 4511-4517.
Wang, X. Y.; Song, P. S.; Peng, L.; Tong, A. J.; Xiang, Y.*, Aggregation-Induced Emission Luminogen-Embedded Silica Nanoparticles Containing DNA Aptamers for Targeted Cell Imaging. ACS Applied Materials & Interfaces 2016, 8, 609-616.
Peng, L.; Zheng, Y.; Wang, X. Y.; Tong, A. J.; Xiang, Y.*, Photoactivatable Aggregation-Induced Emission Fluorophores with Multiple-Color Fluorescence and Wavelength-Selective Activation. Chemistry-a European Journal 2015, 21, 4326-4332.
Tao, J.; Song, P. S.; Sato, Y.; Nishizawa, S.; Teramae, N.; Tong, A. J.; Xiang, Y.*, A Label-Free and Sensitive Fluorescent Method for the Detection of Uracil-DNA Glycosylase Activity. Chemical Communications 2015, 51, 929-932.

As coauthor (non-corresponding) since PI

Zhang, C.; Zheng, Y.; Ding, Y. W.; Zheng, X. K.; Xiang, Y.; Tong, A. J.*, A Ratiometric Solid AIE Sensor for Detection of Acetone Vapor. Talanta 2022, 236, 122845.
Zheng, X. K.; Wu, W. B.; Zheng, Y.; Ding, Y. W.; Xiang, Y.; Liu, B.; Tong, A. J.*, Organic Nanoparticles with Persistent Luminescence for in vivo Afterglow Imaging-Guided Photodynamic Therapy. Chemistry-a European Journal 2021, 27, 6911-6916.
Zheng, Y.; Ding, Y. W.; Zheng, X. K.; Zhang, C.; Zhang, Y. L.; Xiang, Y.; Tong, A. J.*, Long-Term Dynamic Imaging of Cellular Processes Using an AIE Lipid Order Probe in the Dual-Color Mode. Analytical Chemistry 2021, 93, 10272-10281.
Zheng, Y.; Ding, Y. W.; Ren, J. J.; Xiang, Y.; Shuai, Z. G.*; Tong, A. J.*, Simultaneously and Selectively Imaging a Cytoplasm Membrane and Mitochondria Using a Dual Colored Aggregation-Induced Emission Probe, Analytical Chemistry, 2020, 11, 14494-14500.
Zheng, Y.; Panatdasirisuk, W.; Liu, J. Q.; Tong, A. J.; Xiang, Y.; Yang, S.*, Patterned, Wearable UV Indicators from Electrospun Photochromic Fibers and Yarns, Advanced Materials Technology, 2020, 5, 2000564.
Peng, L.; Wei, R. R.; Guo, Y. F.; Zheng, X. K.; Zheng, Y.; Ding, Y. W.; Xiang, Y.; Tong, A. J.*, Tuning Emission Wavelength of Polymorphous Crystal via Controllable Alkyl Chain Stacking and Its Vapor- and Thermo-Responsive Fluorescence. Chemistry-a European Journal 2019, 25, 8043-8052.
Peng, L.; Xiao, L.; Ding, Y. W.; Xiang, Y.; Tong, A. J.*, A Simple Design of Fluorescent Probes for Indirect Detection of Beta-Lactamase Based on AIE and ESIPT Processes. Journal of Materials Chemistry B 2018, 6, 3922-3926.
Zheng, Y.; Zheng, X. K.; Xiang, Y.; Tong, A. J.*, Photoactivatable Aggregation-Induced Emission of Triphenylmethanol. Chemical Communications 2017, 53, 11130-11133.
Zhang, X. K.; Zheng, Y.; Peng, L.; Xiang, Y.; Tong, A. J.*, Mechanoresponsive Fluorescence of 2-Aminobenzophenone Derivatives Based on Amorphous Phase to Crystalline Transformation with High "Off On" Contrast Ratio. Journal of Physical Chemistry C 2017, 121, 21610-21615.
Chen, X. T.*; Peng, L.; Feng, M. L.; Xiang, Y.; Tong, A. J.; He, L. F.; Liu, B.; Tang, Y. P., An Aggregation Induced Emission Eenhancement-Based Ratiometric Fluorescent Sensor for Detecting Trace Uranyl Ion (UO22+) and the Application in Living Cells Imaging. Journal of Luminescence 2017, 186, 301-306.
Li, Y. J.; Wang, C.; Zhu, Y. B.; Zhou, X. H.; Xiang, Y.; He, M.; Zeng, S. Y.*, Fully Integrated Graphene Electronic Biosensor for Label-free Detection of Lead (II) Ion Based on G-Quadruplex Structure-Switching. Biosensors and Bioelectronics 2017, 89, 758-763.
Li, J. L.; Chen, Z. P.; Xiang, Y.; Zhou, L. L.; Wang, T.; Zhang, Z.; Sun, K. X.; Yin, D.; Li, Y.; Xie, G. M.*, An Electrochemical Biosensor for Double-Stranded Wnt7B Gene Detection Based on Enzymatic Isothermal Amplification. Biosensors and Bioelectronics 2016, 86, 75-82.
Zhang, J. J.; Shen, Z.; Xiang, Y.; Lu, Y.*, Integration of Solution-Based Assays onto Lateral Flow Device for One-Step Quantitative Point-of-Care Diagnostics Using Personal Glucose Meter. ACS Sensors 2016, 1, 1091-1096.
Zhang, Z.; Li, J. L.; Yao, J.; Wang, T.; Yin, D.; Xiang, Y.; Chen, Z. P.; Xie, G. M.*, Energy Driven Cascade Recognition for Selective Detection of Nucleic Acids with High Discrimination Factor at Room Temperature. Biosensors & Bioelectronics 2016, 79, 488-494.
Zhang, J. J.; Xiang, Y.; Wang, M.; Basu, A.; Lu, Y.*, Dose-Dependent Response of Personal Glucose Meters to Nicotinamide Coenzymes: Applications to Point-of-Care Diagnostics of Many Non-Glucose Targets in a Single Step. Angewandte Chemie-International Edition 2016, 55 (2), 732-736.
Han, S. T.; Zhou, X. H.; Tang, Y. F.; He, M.*; Zhang, X. Y.; Shi, H. C.; Xiang, Y., Practical, Highly Sensitive, and Regenerable Evanescent-Wave Biosensor for Detection of Hg2+ and Pb2+ in Water. Biosensors & Bioelectronics 2016, 80, 265-272.
Zhou, Z. J.; Xiao, L.; Xiang, Y.; Zhou, J.; Tong, A. J.*, A General Approach for Rational Design of Fluorescent DNA Aptazyme Sensors Based on Target-Induced Unfolding of DNA Hairpins. Analytica Chimica Acta 2015, 889, 179-186.
Zhang, J. J.; Xiang, Y.; Novak, D. E.; Hoganson, G. E.; Zhu, J. J.; Lu, Y.*, Using a Personal Glucose Meter and Alkaline Phosphatase for Point-of-Care Quantification of Galactose-1-Phosphate Uridyltransferase in Clinical Galactosemia Diagnosis. Chemistry-an Asian Journal 2015, 10 (10), 2221-2227.
Yang, J.; Xiang, Y.; Song, C.; Liu, L. Z.; Jing, X. Y.; Xie, G. M.*; Xiang, H.*, Quadruple Signal Amplification Strategy Based on Hybridization Chain Reaction and an Immunoelectrode Modified with Graphene Sheets, a Hemin/G-Quadruplex DNAzyme Concatamer, and Alcohol Dehydrogenase: Ultrasensitive Determination of Influenza Virus Subtype H7n9. Microchimica Acta 2015, 182 (15-16), 2377-2385.
Yan, D. J.; Yuan, H.; Li, W.; Xiang, Y.; He, B.; Nie, C. M.; Wen, G. B.; Lin, Y. W.*; Tan, X. S.*, How a Novel Tyrosine-Heme Cross-Link Fine-Tunes the Structure and Functions of Heme Proteins: A Direct Comparitive Study of L29h/F43y Myoglobin. Dalton Transactions 2015, 44 (43), 18815-18822.
Yan, D. J.; Li, W.; Xiang, Y.; Wen, G. B.; Lin, Y. W.*; Tan, X. S.*, A Novel Tyrosine-Heme C-O Covalent Linkage in F43y Myoglobin: A New Post-Translational Modification of Heme Proteins. Chembiochem 2015, 16 (1), 47-50.
Wang, R. Y.; Xiang, Y.; Zhou, X. H.*; Liu, L. H.; Shi, H. C., A Reusable Aptamer-Based Evanescent Wave All-Fiber Biosensor for Highly Sensitive Detection of Ochratoxin A. Biosensors & Bioelectronics 2015, 66, 11-18.
Liu, H. L.; Wei, R. R.; Xiang, Y.; Tong, A. J.*, Fluorescence Turn-on Detection of Pyrophosphate Based on Aggregation-Induced Emission Property of 5-Chlorosalicylaldehyde Azine. Analytical Methods 2015, 7 (2), 753-758.
Liu, H. L.; Wang, X. Y.; Xiang, Y.; Tong, A. J.*, Fluorescence Turn-on Detection of Cysteine over Homocysteine and Glutathione Based on "Esipt" and "Aie". Analytical Methods 2015, 7 (12), 5028-5033.
Zhou, Z. J.; Xiang, Y.; Tong, A. J.*; Lu, Y.*, Simple and Efficient Method to Purify DNA-Protein Conjugates and Its Sensing Applications. Analytical Chemistry 2014, 86 (8), 3869-3875.
Zhou, Z. J.; Peng, L.; Wang, X. Y.; Xiang, Y.; Tong, A. J.*, A New Colorimetric Strategy for Monitoring Caspase 3 Activity by Hrp-Mimicking DNAzyme-Peptide Conjugates. Analyst 2014, 139 (5), 1178-1183.
Song, P. S.; Xiang, Y.; Wei, R. R.; Tong, A. J.*, A Fluorescent Chemosensor for Cu2+ Detection in Solution Based on Aggregation-Induced Emission and Its Application in Fabricating Cu2+ Test Papers. Journal of Luminescence 2014, 153, 215-220.
Peng, L.; Zhou, Z. J.; Wang, X. Y.; Wei, R. R.; Li, K.; Xiang, Y.; Tong, A. J.*, A Ratiometric Fluorescent Chemosensor for Al3+ in Aqueous Solution Based on Aggregation-Induced Emission and Its Application in Live-Cell Imaging. Analytica Chimica Acta 2014, 829, 54-59.
Li, K.; Xiang, Y.; Wang, X. Y.; Li, J.; Hu, R. R.; Tong, A. J.*; Tang, B. Z.*, Reversible Photochromic System Based on Rhodamine B Salicylaldehyde Hydrazone Metal Complex. Journal of the American Chemical Society 2014, 136 (4), 1643-1649.
Li, K.; Xiang, Y.; Tong, A. J.*; Tang, B. Z.*, Readily Accessible Rhodamine B-Based Photoresponsive Material. Science China-Chemistry 2014, 57 (2), 248-251.

Works during PhD and Postdoc

Xiang, Y.; Wu, P. W.; Tan, L. H.; Lu, Y.*, DNAzyme-Functionalized Gold Nanoparticles for Biosensing. In Biosensors Based on Aptamers and Enzymes, Gu, M. B.; Kim, H. S., Eds. 2014, pp 93-120.
Xiang, Y.; Lu, Y.*, DNA as Sensors and Imaging Agents for Metal Ions. Inorganic Chemistry 2014, 53 (4), 1925-1942.
Xiang, Y.; Wang, Z. D.; Xing, H.; Lu, Y.*, Expanding DNAzyme Functionality through Enzyme Cascades with Applications in Single Nucleotide Repair and Tunable DNA-Directed Assembly of Nanomaterials. Chemical Science 2013, 4 (1), 398-404.
Xiang, Y.; Lu, Y.*, An Invasive DNA Approach toward a General Method for Portable Quantification of Metal Ions Using a Personal Glucose Meter. Chemical Communications 2013, 49 (6), 585-587.
Xing, H.; Wong, N. Y.; Xiang, Y.; Lu, Y.*, DNA Aptamer Functionalized Nanomaterials for Intracellular Analysis, Cancer Cell Imaging and Drug Delivery. Current Opinion in Chemical Biology 2012, 16 (3-4), 429-435.
Xing, H.; Wang, Z. D.; Xu, Z. D.; Wong, N. Y.; Xiang, Y.; Liu, G. L. G.; Lu, Y.*, DNA-Directed Assembly of Asymmetric Nanoclusters Using Janus Nanoparticles. ACS Nano 2012, 6 (1), 802-809.
Xiang, Y.; Lu, Y.*, Using Commercially Available Personal Glucose Meters for Portable Quantification of DNA. Analytical Chemistry 2012, 84 (4), 1975-1980.
Xiang, Y.; Lu, Y.*, Portable and Quantitative Detection of Protein Biomarkers and Small Molecular Toxins Using Antibodies and Ubiquitous Personal Glucose Meters. Analytical Chemistry 2012, 84 (9), 4174-4178.
Xiang, Y.; Lu, Y.*, Expanding Targets of DNAzyme-Based Sensors through Deactivation and Activation of DNAzymes by Single Uracil Removal: Sensitive Fluorescent Assay of Uracil-DNA Glycosylase. Analytical Chemistry 2012, 84 (22), 9981-9987.
Song, P. S.; Xiang, Y.; Xing, H.; Zhou, Z. J.; Tong, A. J.*; Lu, Y.*, Label-Free Catalytic and Molecular Beacon Containing an Abasic Site for Sensitive Fluorescent Detection of Small Inorganic and Organic Molecules. Analytical Chemistry 2012, 84 (6), 2916-2922.
Liu, H.; Xiang, Y.; Lu, Y.; Crooks, R. M.*, Aptamer-Based Origami Paper Analytical Device for Electrochemical Detection of Adenosine. Angewandte Chemie-International Edition 2012, 51 (28), 6925-6928.
Xiang, Y.; Lu, Y.*, Using Personal Glucose Meters and Functional DNA Sensors to Quantify a Variety of Analytical Targets. Nature Chemistry 2011, 3 (9), 697-703.
Song, P. S.; Chen, X. T.; Xiang, Y.; Huang, L.; Zhou, Z. J.; Wei, R. R.; Tong, A. J.*, A Ratiometric Fluorescent Ph Probe Based on Aggregation-Induced Emission Enhancement and Its Application in Live-Cell Imaging. Journal of Materials Chemistry 2011, 21 (35), 13470-13475.
Chen, X. T.; Xiang, Y.; Song, P. S.; Wei, R. R.; Zhou, Z. J.; Li, K.; Tong, A. J.*, P-Carboxyl-N-Salicylideneanilines: Simple but Efficient Chromophores for One-Dimensional Microrods with Aggregation-Induced Emission Enhancement (Aiee) Characteristics. Journal of Luminescence 2011, 131 (7), 1453-1459.
Chen, X. T.; Wei, R. R.; Xiang, Y.; Zhou, Z. J.; Li, K.; Song, P. S.; Tong, A. J.*, Organic Crystalline Solids Response to Piezo/Thermo Stimulus: Donor-Acceptor (D-a) Attached Salicylaldehyde Azine Derivatives. Journal of Physical Chemistry C 2011, 115 (29), 14353-14359.
Zhang, X. B.; Wang, Z. D.; Xing, H.; Xiang, Y.; Lu, Y.*, Catalytic and Molecular Beacons for Amplified Detection of Metal Ions and Organic Molecules with High Sensitivity. Analytical Chemistry 2010, 82 (12), 5005-5011.
Xiang, Y.; Wang, Z. D.; Xing, H.; Wong, N. Y.; Lu, Y.*, Label-Free Fluorescent Functional DNA Sensors Using Unmodified DNA: A Vacant Site Approach. Analytical Chemistry 2010, 82 (10), 4122-4129.
Li, N.; Xiang, Y.; Tong, A. J.*, Highly Sensitive and Selective "Turn-on" Fluorescent Chemodosimeter for Cu2+ in Water Via Cu2+-Promoted Hydrolysis of Lactone Moiety in Coumarin. Chemical Communications 2010, 46 (19), 3363-3365.
Li, N.; Tang, W. X.; Xiang, Y.; Tong, A. J.*; Jin, P. Y.; Ju, Y., Fluorescent Salicylaldehyde Hydrazone as Selective Chemosensor for Zn2+ in Aqueous Ethanol: A Ratiometric Approach. Luminescence 2010, 25 (6), 445-451.
Chen, X. T.; Xiang, Y.; Tong, A. J.*, Facile, Sensitive and Selective Fluorescence Turn-on Detection of Hsa/Bsa in Aqueous Solution Utilizing 2,4-Dihydroxyl-3-Iodo Salicylaldehyde Azine. Talanta 2010, 80 (5), 1952-1958.
Chen, X. T.; Xiang, Y.; Li, N.; Song, P. S.; Tong, A. J.*, Fluorescence Turn-on Detection of Protamine Based on Aggregation-Induced Emission Enhancement Characteristics of 4-(6 '-Carboxyl)Hexyloxysalicylaldehyde Azine. Analyst 2010, 135 (5), 1098-1105.
Xiang, Y.; Tong, A. J.*; Lu, Y.*, Abasic Site-Containing DNAzyme and Aptamer for Label-Free Fluorescent Detection of Pb2+ and Adenosine with High Sensitivity, Selectivity, and Tunable Dynamic Range. Journal of the American Chemical Society 2009, 131 (42), 15352-15357.
Tang, W. X.; Xiang, Y.*; Tong, A. J.*, Salicylaldehyde Azines as Fluorophores of Aggregation-Induced Emission Enhancement Characteristics. Journal of Organic Chemistry 2009, 74 (5), 2163-2166.
Li, N.; Xiang, Y.; Chen, X. T.; Tong, A. J.*, Salicylaldehyde Hydrazones as Fluorescent Probes for Zinc Ion in Aqueous Solution of Physiological Ph. Talanta 2009, 79 (2), 327-332.
Cui, W.; Ma, J. W.; Lei, P.; Wu, W. H.; Yu, Y. P.; Xiang, Y.; Tong, A. J.; Zhao, Y. F.; Li, Y. M.*, Insulin Is a Kinetic but Not a Thermodynamic Inhibitor of Amylin Aggregation. FEBS Journal 2009, 276 (12), 3365-3371.
Xiang, Y.; Tong, A.*, Ratiometric and Selective Fluorescent Chemodosimeter for Cu(Ii) by Cu(Ii)-Induced Oxidation. Luminescence 2008, 23 (1), 28-31.
Xiang, Y.; Li, M.; Chen, X. T.; Tong, A. J.*, Highly Sensitive and Selective Optical Chemosensor for Determination of Cu2+ in Aqueous Solution. Talanta 2008, 74 (5), 1148-1153.
Li, Z. F.; Xiang, Y.; Tong, A.*, Ratiometric Chemosensor for Fluorescent Determination of Zn2+ in Aqueous Ethanol. Analytica Chimica Acta 2008, 619 (1), 75-80.
Li, Z. F.; Mei, L.; Xiang, Y.; Tong, A. J.*, Novel Colorogenic Probe of Rhodamine B Derivative for the Detection or Copper Ion. Chinese Journal of Analytical Chemistry 2008, 36 (7), 915-919.
Chen, X. T.; Xiang, Y.; Li, Z. F.; Tong, A. J.*, Sensitive and Selective Fluorescence Determination of Trace Hydrazine in Aqueous Solution Utilizing 5-Chlorosalicylaldehyde. Analytica Chimica Acta 2008, 625 (1), 41-46.
Chen, X. T.; Li, Z. F.; Xiang, Y.; Tong, A. J.*, Salicylaldehyde Fluorescein Hydrazone: A Colorimetric Logic Chemosensor for Ph and Cu(Ii). Tetrahedron Letters 2008, 49 (32), 4697-4700.
Xiang, Y.; Mei, L.; Li, N.; Tong, A. J.*, Sensitive and Selective Spectrofluorimetric Determination of Chromium(Vi) in Water by Fluorescence Enhancement. Analytica Chimica Acta 2007, 581 (1), 132-136.
Mei, L.; Xiang, Y.; Li, N.; Tong, A. J.*, A New Fluorescent Probe of Rhodamine B Derivative for the Detection of Copper Ion. Talanta 2007, 72 (5), 1717-1722.
Li, N.; Mei, L.; Xiang, Y.; Tong, A. J.*; Nishizawa, S.; Teramae, N., Fluorescence Detection of Single-Nucleotide Polymorphisms with Two Simple and Low Cost Methods: A Double-DNA-Probe Method and a Bulge Form Method. Analytica Chimica Acta 2007, 597 (1), 97-102.
Xiang, Y.; Tong, A. J.*; Jin, P. Y.; Ju, Y., New Fluorescent Rhodamine Hydrazone Chemosensor for Cu(Ii) with High Selectivity and Sensitivity. Organic Letters 2006, 8 (13), 2863-2866.
Xiang, Y.; Tong, A. J.*, A New Rhodamine-Based Chemosensor Exhibiting Selective Fe-Iii-Amplified Fluorescence. Organic Letters 2006, 8 (8), 1549-1552.
Xiang, Y.; Tong, A. J.*, Simple and Efficient Ratiometric Fluorescent Probes for near-Neutral Ph in Aqueous Solutions. Chemistry Letters 2005, 34 (7), 926-927.